The Sir Mortimer B. Davis-Jewish general Hospital
$150,000.00 CAD
- Department
- Canadian Space Agency
- Recipient country
- Canada
- Fiscal year
- 2023-2024
- Agreement period
- September 26, 2023 – September 30, 2025
- Reference
- csa-asc:003-2023-2024-Q2-00006
Published purpose
Muscle wasting occurs in consequence to pathological conditions, including aging (sarcopenia). In space, healthy astronauts experience severe wasting of the anti-gravity muscles, the muscles that are normally engaged on Earth to maintain posture. Adjunct therapies are required to mitigate the risk of muscle wasting to enable human exploration of space. In this proposal, the research team use genetic tools in the mouse to reveal how protein synthesis, a major determinant of muscle mass, is remodeled in aging mice. Understanding how protein synthesis is remodeled under conditions of muscle wasting on Earth and in space is the first step towards identifying drug targets.
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