Concordia University

Published purpose

Encapsulation technology with macromolecules of long chains with large molecular weights is a promising platform for the delivery of bio-active molecules such as proteins and nucleic acids. This technology ensures not only the reproducible formulation with their precise dosage but also the controlled release kinetics of encapsulated biomolecules in targeting areas such as tissues. Compared with man-made polymers, naturally-occurring biopolymers such as polysaccharides produced from biomasses are biocompatible and non-toxic to environments. In collaboration with a NRC team, the Prof Oh' group at Concordia University will develop a new strategy utilizing stimuli-responsive degradation that allows for the modification of a naturally-occurring cationic macromolecule encapsulating anionic biomolecules such as nucleic acids and proteins. Further, the macromolecules will be designed with multifunctionalities exhibiting biodegradablity in response to soil pH and volume change in response to temperature change that can facilitate the controlled release of cargos. It can be anticipated that the develop encapsulation technology is robust and efficient enough to promote the efficient delivery of bio-active molecules acting as pesticides and growth promoters to improve crop yields in agricultural farm lands.