Corporation de l'École Polytechnique de Montréal
$99,880.00 CAD
≈ 15 months of average Canadian pay
- Department
- National Research Council Canada
- Recipient country
- Canada
- Fiscal year
- 2020-2021
- Agreement period
- January 25, 2021 – March 31, 2022
- Reference
- nrc-cnrc:172-2021-2022-Q4-964421
Published purpose
This Project has two objectives: 1. Acquiring an understanding of the Covid-19 viral translocation mechanism at the molecular level. More specifically, it will investigate if/how glycosylation of the viral spike protein and human angiotensin converting enzyme 2 (ACE2) receptor modulates binding, and 2. How the glycan structure of the ADCC-attenuated Fc D270G mutant (Fc1X7) structure impacts interaction between Fcγ and FcRn receptors. The Fc1X7 is used as a fusion partner for COVID-19 therapeutic proteins and the information generated here will provide important information about enhancing their efficacy and safety.
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Imported July 30, 2026 from open.canada.ca Grants & Contributions