Concordia University

Published purpose

The genome foundry is a technology platform that provides an integrated infrastructure enabling the rapid design, construction, and testing of genetically engineered cells or organisms for bio-technology applications and research. The foundry is composed of a computational biology pipeline that integrates this workflow coupled to an integrated suite of robotic equipment specifically configured to automate standard molecular biology procedures required for cellular engineering in an automated and high-throughput (HTP) fashion. The overarching goal is to establish biodesign rules and methods that can be applied towards the efficient engineering of mammalian cells for biotechnology and biomedical applications. Precise and rapid cellular engineering not only allows fundamental insights into the complexity of living systems but also supports the growth of a robust engineering/synthetic biology industry and accelerates the commercialization of biomanufacturing and novel engineered cell therapies. This Project supports the development of the foundry's precision editing platform to accelerate engineering of enhanced safety, efficacy and allogeneic-cell based therapies.